英国的Maurice Elphick教授现在招收CSC的博士生(Queen Mary, University of London)，教授做神经肽的研究，有生物背景的同学如果感兴趣的话可以联系他，e-mail (m.r.elphick@qmul.ac.uk)

　　Maurice Elphick教授的具体信息，请参见以下链接：

　　http://www.sbcs.qmul.ac.uk/staff/mauriceelphick.html

　　http://www.researchpublications. ... ns/staff/21463.html

　　http://scholar.google.co.uk/citations?user=SBj_WCcAAAAJ&hl=en

　　http://www.researchgate.net/profile/Maurice_Elphick/

　　Comparative physiology and evolution of neuropeptide signalling

　　Neuropeptides and peptide hormones have fundamental roles in controlling, regulating and integrating physiological and behavioural processes in humans and other animals. I am interested in reconstructing the evolutionary history of neuropeptide signalling systems and investigating how neuropeptides are utilised to co-ordinate physiological processes and behaviour in animals.

　　The primary focus of my neuropeptide research is on echinoderms (starfish, sea urchins, sea cucumbers), which are of special interest for a number of reasons. Firstly, as deuterostomes, echinoderms are much more closely related to vertebrates than the majority of invertebrates, and therefore research on echinoderms can shed light on the evolutionary origins of vertebrate characters. Secondly, echinoderms have many remarkable morphological and physiological characteristics – they are typically five-sided and have a unique ability to rapidly change (under neural control) the stiffness of body wall collagenous tissue; they also have remarkable powers of regeneration, which makes them of great interest from a medical perspective. Thirdly, echinoderms (sea cucumbers, sea urchins) are of economic importance as sources of food in China and other Asian countries.

　　I pioneered research on neuropeptides in echinoderms with the discovery of the SALMFamide neuropeptide family (Elphick et al., 1991). Now twenty years later we are entering a new era for research on neuropeptide systems in echinoderms. Sequencing of the genomes/transcriptomes of several echinoderm species is providing fascinating new insights on the evolution and diversity of neuropeptide systems (Rowe and Elphick, 2012; Elphick, 2012). Moreover,

　　with the falling cost of DNA sequencing, any echinoderm species is now accessible to transcriptomic analysis of neuropeptide systems. For the first time we can comprehensively investigate neuropeptide function in animals that hitherto were intractable for molecular physiological studies. Utilising recently obtained neural transcriptome data, my lab is using the common starfish Asterias rubens as a model system to investigate the evolution and physiological roles of neuropeptide systems and I welcome applications from students interested in PhD projects in this field of research.

　　Training in a wide-range of research techniques will be provided, including bioinformatics, genomics, transcriptomics, peptidomics, molecular histology, in vitro pharmacology and behavioural studies. Personalised training in writing and communication skills will be provided, complemented with generic transferable skills training from the QMUL Learning Institute.

　　Publications: For further details of the recent publications from the Elphick lab see: http://www.researchpublications. ... ns/staff/21463.html

　　APPLICANT SPECIFICATIONS

　　I welcome applications from students with a B.Sc. degree (1st class) in Biology, Zoology, Physiology, Neuroscience, Molecular/Cellular Biology, Pharmacology or Biochemistry. A M.Sc. degree in one these areas is desirable but not essential. Experience of laboratory-based research involving use of one or more of the following techniques would also be desirable, but not essential: bioinformatics; cloning, sequencing and expression of cDNAs; in vitro / in vivo pharmacology; mRNA in situ hybridisation, immunocytochemistry, biomechanics.